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The Global Fund to Fight AIDS, Tuberculosis, and Malaria has announced a historic surge in private sector support, with US$1.34 billion mobilized for its Eighth Replenishment.
Combined with earlier contributions since the Seventh Replenishment conference in 2022, the total now stands at US$1.49 billion, the largest wave of private sector backing in the Global Fund’s history.
Co-hosted by the governments of the Republic of South Africa and the United Kingdom on the margins of the G20 Leaders’ Summit, this year’s replenishment arrives amid growing economic uncertainty and geopolitical instability.
Still, the scale and speed of commitments demonstrate a shared urgency to accelerate innovation, expand equity, and strengthen health systems that can withstand present and future threats.
Private sector funding remains critical to enabling the Global Fund to move quickly, especially in expanding access to lifesaving tools such as lenacapavir and next-generation TB diagnostics.
These investments ensure that communities receive the most effective interventions more rapidly and more equitably, particularly in regions where progress against AIDS, TB, and malaria remains fragile.
“What we are witnessing here is the power of bold, agile leadership. The private sector has stepped forward at a critical moment, acting swiftly and at scale to save lives and spur the engagement of other stakeholders,” said Peter Sands, Executive Director of the Global Fund.
A total of 21 companies, foundations, and philanthropists have contributed through financial pledges and co-investments.
Their commitments are helping shape market pathways, strengthen integrated health systems, and expand support for vulnerable communities most at risk of AIDS, TB, and malaria.
The Bill & Melinda Gates Foundation, the Global Fund’s largest private donor, pledged US$912 million in September, raising its cumulative support since 2002 to nearly US$5 billion.
(RED) renewed its long-standing partnership with a US$75 million commitment.
The Children’s Investment Fund Foundation (CIFF) pledged US$50 million to expand TB diagnostics, complementing its previous US$150 million investment to reduce HIV transmission, among other interventions.
Sands emphasized the importance of sustaining this momentum, adding, “Now we must build on this momentum. We invite others to join us in demonstrating how private sector dollars and capabilities can have such an extraordinary catalytic impact.”
Several partners stepped forward with non-financial and co-investment commitments, providing technical assistance to strengthen diagnostic ecosystems, improve health-care waste management, optimize national supply chains, and support the digital transformation of health systems.
These contributions include expanding the use of advanced AI, strengthening behavior change and prevention programs, and improving logistics to ensure essential health products reach communities efficiently and consistently.
Together, these commitments reflect the private sector’s growing resolve to invest in innovation, expand access, and ensure lifesaving tools reach the people who need them most.
They also highlight an evolving understanding that private capital, expertise, and technology are central to building resilient health systems capable of withstanding future global health challenges.
As leaders emphasized at the Summit, momentum must continue as the Global Fund advances toward its US$2 billion private sector goal, deepening collaboration and scaling innovations that deliver measurable global health impact.
